1H-1,2,4- triazole

Name: 1H-1,2,4- triazole
Brand: HELY SPECIALITY CHEMICALS
Price: 450 INR
Availability: InStock

450 INR/Kilograms

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1H-1,2,4- triazole Price And Quantity

Minimum Order Quantity 1000 Kilograms
Price 450 INR/Kilograms

Stability Stable under normal storage conditions
Density 1.32 g/cm (at 20C)
Melting Point 119-121C
Boiling Point 260C
CAS No. 288-88-0
Flash Point 149C
Purity 99%
Applications Pharmaceuticals, agrochemicals, intermediates, research and development
HS Code 2933.99
Appearance White to off-white crystalline powder
Solubility Soluble in water, ethanol, and acetone
Refractive Index 1.502
Product Name 1H-1,2,4-Triazole
EC Number 206-019-2
Molecular Weight 69.07 g/mol
Molecular Formula C2H3N3
Storage Store in a cool, dry, and well-ventilated area
Shelf Life 24 months from date of manufacture
Molar Mass 69.07 g/mol
pH (1% solution) Approx. 6.5-7.5

1H-1,2,4- triazole Trade Information

Supply Ability 1000 Kilograms Per Day
Delivery Time 1 Week
Sample Available Yes
Sample Policy Contact us for information regarding our sample policy

Product Description

1H124Triazole is a heterocyclic compound containing a fivemembered ring made up of three nitrogen atoms and two carbon atoms with a hydrogen atom attached to one of the nitrogen atoms in the ring It is one of the most common triazole derivatives and has significant importance in chemistry and various fields such as pharmaceuticals and material science

Chemical Details

IUPAC Name 1H124Triazole

Molecular Formula C3H3N3

Molecular Weight 6907 gmol

Structure

A triazole ring with nitrogen atoms at positions 1 2 and 4 The H in 1H refers to the hydrogen atom at the 1position

Physical Properties

Appearance Colorless to pale yellow crystalline solid

Melting Point 7072C

Boiling Point 175C

Solubility Soluble in water and polar organic solvents like ethanol and acetone

Density 125 gcm

Applications

1 Pharmaceuticals

Antifungal Activity 1H124triazole derivatives are widely used as antifungal agents For example fluconazole itraconazole and voriconazole are derived from the triazole ring structure and are used to treat various fungal infections by inhibiting ergosterol biosynthesis

Anticancer Potential Triazole derivatives are also explored for their anticancer properties particularly in inhibiting enzymes involved in DNA synthesis and repair

Antiinflammatory and Antibacterial Activity Some derivatives show promise in antiinflammatory and antibacterial applications

2 Agriculture

Fungicides Triazole compounds are used as fungicides in agriculture due to their ability to inhibit the biosynthesis of ergosterol which is crucial for fungal cell membranes

Herbicides and Growth Regulators Some triazole derivatives are used to modify plant growth or as plant growth regulators in crops

3 Materials Science

Coordination Chemistry The nitrogen atoms in the triazole ring can coordinate with metal centers making 1H124triazole useful in the synthesis of metalorganic frameworks MOFs or other coordination compounds

Polymer Chemistry Triazole derivatives are used in the synthesis of specialized polymers often to impart unique properties like resistance to oxidation or enhanced mechanical strength

4 Chemical Synthesis

Ligands in Organic Synthesis The triazole ring acts as a bidentate ligand for metals widely used in catalysis

Reagents in Organic Synthesis 1H124Triazole is used as a building block in the synthesis of other functionalized heterocycles or complex organic molecules

Chemical Reactivity

1 Nucleophilic Substitution

The nitrogen atoms in the 124triazole ring can act as nucleophiles enabling substitution reactions in organic synthesis

2 Electrophilic Aromatic Substitution

The triazole ring is activated at the positions 3 and 5 relative to the nitrogen atoms making it reactive in electrophilic substitution reactions

3 Coordination Chemistry

The nitrogen atoms in the triazole ring can coordinate with metal centers forming stable chelates useful in catalytic processes or material science

Synthesis of 1H124Triazole

1 From Hydrazine Derivatives

One common synthetic route involves the reaction of hydrazine with an unsaturated ketone or other appropriate reagents to form the triazole ring

2 Via Cyclization of Azides

Triazoles can be synthesized by cyclization of azides with alkynes or other electrophilic reagents providing a straightforward method for constructing the ring

3 From Amidrazones or Hydrazones

Cyclization of amidrazones or hydrazones with appropriate electrophiles or acid catalysts leads to 1H124triazole

Safety and Handling

Toxicity

1H124Triazole and its derivatives should be handled with care as they may be harmful if ingested inhaled or absorbed through the skin

It may cause irritation to the skin eyes and respiratory system

Precautions

Use gloves protective eyewear and work in a wellventilated fume hood Always follow safety guidelines for handling chemicals

Storage

Store in a cool dry place away from heat moisture and strong oxidizers Ensure containers are tightly sealed

Would you like additional information on specific derivatives of 1H124triazole its role in drug design or its use in coordination chemistry

Exceptional Stability and Purity

1H-1,2,4-Triazole offers notable stability and purity, making it well-suited for demanding industrial and research environments. The compound remains stable under standard storage conditions, and its purity of at least 99% ensures consistent and reliable results in various formulations and synthesis processes.

Wide Range of Applications

This triazole derivative is highly respected for its adaptability in pharmaceuticals, where it serves as a critical intermediate, and in agrochemicals for crop protection. Researchers and manufacturers also utilize it due to its comprehensive solubility in water and organic solvents, enabling straightforward integration into diverse chemical processes.

Safe Handling and Storage

1H-1,2,4-Triazole should be stored in a cool, dry, and well-ventilated area. Proper storage preserves its quality throughout its 24-month shelf life and ensures user safety, given its high flash point and stable crystalline nature. Adherence to storage guidelines is paramount for maintaining product integrity.

FAQ's of 1H-1,2,4- triazole:

Q: How should 1H-1,2,4-Triazole be stored to maintain its stability?

A: 1H-1,2,4-Triazole should be stored in a cool, dry, and well-ventilated area, away from sources of moisture and heat. When properly stored, it maintains stability and optimal performance for up to 24 months from the date of manufacture.

Q: What are the common uses and applications of 1H-1,2,4-Triazole?

A: 1H-1,2,4-Triazole is primarily utilized as an intermediate in pharmaceutical manufacturing, agrochemical production, and research and development. Its chemical properties make it valuable for synthesizing various compounds and enhancing process efficiency.

Q: When can 1H-1,2,4-Triazole be included in chemical synthesis or formulations?

A: 1H-1,2,4-Triazole can be incorporated into formulations and reaction schemes whenever a stable, high-purity triazole ring is required, especially in the development of pharmaceuticals and agrochemicals.

Q: Where is 1H-1,2,4-Triazole typically supplied and traded in India?

A: 1H-1,2,4-Triazole is widely distributed by manufacturers, suppliers, and traders across India. It is readily available for industrial, academic, and commercial use from established distributors.

Q: What is the process of using 1H-1,2,4-Triazole in research and development?

A: Researchers use 1H-1,2,4-Triazole in the synthesis of novel compounds by dissolving it in compatible solvents such as water, ethanol, or acetone, leveraging its high purity to achieve accurate experimental results.

Q: What are the benefits of using 1H-1,2,4-Triazole in pharmaceutical production?

A: Its high purity ( 99%), excellent solubility, and stability ensure reliable performance and reproducibility, making it a preferred building block for active pharmaceutical ingredients and other specialty chemicals.

Q: How should 1H-1,2,4-Triazole be handled safely during use?

A: Use personal protective equipment and handle the compound in a well-ventilated area. Avoid direct contact with skin or eyes, and ensure good practices for chemical hygiene and storage to safeguard users and maintain product quality.