(R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH)

About (R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH)

R3Carbamoylmethyl5methyl hexanoic acid RCMH is the enantiomerically pure Rform of the compound indicating it is optically active and contains only the Rconfiguration at its chiral center This compound is of interest in medicinal chemistry particularly for its potential role in modulating neurological processes

Structural and Chemical Details

Chemical formula C10H19NO3

Molecular weight 20126 gmol

Chirality The Rconfiguration specifies the spatial arrangement of the groups around the chiral center

Functional Groups

Carboxylic Acid COOH Imparts acidity and potential for forming salts or esters

Carbamoylmethyl Group CH2CONH2 Contributes to hydrogen bonding and potential interactions with biological targets

Methyl Substituent Located on the hexanoic acid backbone influencing hydrophobicity and steric interactions

Pharmaceutical Context

1 Neurological Activity

Similar compounds eg pregabalin act as GABA analogs modulating calcium channels 2 subunit to treat neuropathic pain epilepsy and anxiety The Renantiomer is often the active form in such cases due to stereospecific receptor interactions

2 Enantiomeric Purity

The pharmacological activity and metabolism of chiral compounds can be heavily influenced by their configuration The Renantiomer may exhibit distinct bioactivity compared to the racemic mixture or the Sform

Potential Applications

Therapeutic Research The compound may be explored for its role in

Neuropathic pain management

Seizure modulation

Anxiety treatment

Drug Development Used as a lead compound or intermediate for synthesizing derivatives with improved potency bioavailability or safety

Synthesis

The synthesis of R3Carbamoylmethyl5methyl hexanoic acid typically involves

1 Chiral Resolution Separating the R and Senantiomers from a racemic mixture

2 Asymmetric Synthesis Employing chiral catalysts or reagents to selectively produce the Renantiomer

Let me know if you need more details on synthesis biological activity or a specific application for this compound

Key Applications in Research and Development

RCMH serves as a crucial intermediate in pharmaceutical research, particularly in the synthesis of various active compounds. Its high purity and reliable stability make it suitable for laboratory settings where precision is essential. Researchers and manufacturers commonly select RCMH for both preparative and analytical investigations, ensuring robust experimental results.


Quality and Packaging Assurance

Supplied in secure bottles ranging from 1g to 100g, RCMH is rigorously tested for purity (99% by HPLC), low moisture content (1.0%), and minimal heavy metal presence (10 ppm). This attention to quality supports reproducibility in experiments and compliance with stringent pharmaceutical standards.


Safe Handling and Storage Recommendations

Store RCMH in a cool, dry area away from light to maintain optimal stability throughout its 2-year shelf life. This ensures the compound retains its physical and chemical integrity for use in critical pharmaceutical and research applications.