(R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH)

Name: (R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH)
Brand: HELY SPECIALITY CHEMICALS
Price: 1400 INR
Availability: InStock

1400 INR/Kilograms

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(R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH) Price And Quantity

Minimum Order Quantity 100 Kilograms
Price 1400 INR/Kilograms

Solubility Soluble in water, methanol, DMF
Synonyms (R)-Gabapentin acid; (R)-3-(Carbamoylmethyl)-5-methylhexanoic acid
Packing 1g, 5g, 25g, 100g bottle
Product Name (R)-(-)-3-(Carbamoylmethyl)-5-methyl hexanoic acid (RCMH)
Structural Formula C9H17NO3
Shelf Life 2 years under recommended storage
Boiling Point Not available (decomposes)
HS Code 29241900
Molecular Weight 187.24 g/mol
Appearance White to off-white crystalline powder
Molecular Formula C9H17NO3
Application Pharmaceutical intermediate, research and development
Melting Point 104-106 C
Abbreviation RCMH
Heavy Metals <= 10 ppm
Storage Condition Store in cool, dry place away from light
Grade Pharmaceutical / Research
Purity >= 99%
Chemical Name (R)-(-)-3-(Carbamoylmethyl)-5-methyl hexanoic acid
CAS Number 181289-33-8
Loss on Drying <= 1.0%
Assay (HPLC) >= 99.0 %
pH (1% in water) 5.0 - 7.0
Optical Rotation []D20 -2.0 to -2.5 (c=1, CH3OH)

(R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH) Trade Information

Payment Terms Others
Supply Ability 1000 Kilograms Per Day
Delivery Time 1 Week
Sample Available Yes
Sample Policy Contact us for information regarding our sample policy

Product Description

R3Carbamoylmethyl5methyl hexanoic acid RCMH is the enantiomerically pure Rform of the compound indicating it is optically active and contains only the Rconfiguration at its chiral center This compound is of interest in medicinal chemistry particularly for its potential role in modulating neurological processes

Structural and Chemical Details

Chemical formula C10H19NO3

Molecular weight 20126 gmol

Chirality The Rconfiguration specifies the spatial arrangement of the groups around the chiral center

Functional Groups

Carboxylic Acid COOH Imparts acidity and potential for forming salts or esters

Carbamoylmethyl Group CH2CONH2 Contributes to hydrogen bonding and potential interactions with biological targets

Methyl Substituent Located on the hexanoic acid backbone influencing hydrophobicity and steric interactions

Pharmaceutical Context

1 Neurological Activity

Similar compounds eg pregabalin act as GABA analogs modulating calcium channels 2 subunit to treat neuropathic pain epilepsy and anxiety The Renantiomer is often the active form in such cases due to stereospecific receptor interactions

2 Enantiomeric Purity

The pharmacological activity and metabolism of chiral compounds can be heavily influenced by their configuration The Renantiomer may exhibit distinct bioactivity compared to the racemic mixture or the Sform

Potential Applications

Therapeutic Research The compound may be explored for its role in

Neuropathic pain management

Seizure modulation

Anxiety treatment

Drug Development Used as a lead compound or intermediate for synthesizing derivatives with improved potency bioavailability or safety

Synthesis

The synthesis of R3Carbamoylmethyl5methyl hexanoic acid typically involves

1 Chiral Resolution Separating the R and Senantiomers from a racemic mixture

2 Asymmetric Synthesis Employing chiral catalysts or reagents to selectively produce the Renantiomer

Let me know if you need more details on synthesis biological activity or a specific application for this compound

Key Applications in Research and Development

RCMH serves as a crucial intermediate in pharmaceutical research, particularly in the synthesis of various active compounds. Its high purity and reliable stability make it suitable for laboratory settings where precision is essential. Researchers and manufacturers commonly select RCMH for both preparative and analytical investigations, ensuring robust experimental results.

Quality and Packaging Assurance

Supplied in secure bottles ranging from 1g to 100g, RCMH is rigorously tested for purity (99% by HPLC), low moisture content (1.0%), and minimal heavy metal presence (10 ppm). This attention to quality supports reproducibility in experiments and compliance with stringent pharmaceutical standards.

Safe Handling and Storage Recommendations

Store RCMH in a cool, dry area away from light to maintain optimal stability throughout its 2-year shelf life. This ensures the compound retains its physical and chemical integrity for use in critical pharmaceutical and research applications.

FAQ's of (R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH):

Q: How should (R)-(-)-3-(Carbamoylmethyl)-5-methyl hexanoic acid (RCMH) be stored for maximum shelf life?

A: RCMH should be stored in a cool, dry place away from light. Following these guidelines helps maintain its stability and ensures a shelf life of up to 2 years.

Q: What are the main uses of RCMH in the pharmaceutical industry?

A: RCMH is primarily used as an intermediate in the synthesis of pharmaceutical compounds and is essential for research and development of new drug entities.

Q: When is RCMH typically applied during the drug development process?

A: RCMH is generally introduced at stages involving the chemical synthesis and modification of active pharmaceutical ingredients, especially when specific chiral or structural characteristics are required.

Q: Where is RCMH commonly sourced and supplied?

A: RCMH is manufactured and distributed by specialized chemical suppliers and pharmaceutical distributors, particularly in India, with availability in various pack sizes for research needs.

Q: How is the quality of RCMH ensured before shipment?

A: Each batch of RCMH undergoes rigorous testing for identity (HPLC assay 99%), dryness (1.0%), heavy metals content (10 ppm), and other parameters to meet pharmaceutical and research standards.

Q: What benefits does RCMH offer for laboratory research and process development?

A: RCMH's high purity, aqueous solubility, and well-defined analytical parameters enable reproducible results and consistent performance in research and development settings.